LGI-ADAM interactions

Explorer Adam 22 Is a Major Neuronal Receptor for Lgi 4 - Mediated Schwann Cell Signaling

The segregation and myelination of axons in the developing peripheral nervous system (PNS), results from a complex series of cellular and molecular interactions between Schwann cells and axons. Previously we identified the Lgi4 gene (Leucine-rich-glioma inactivated4) as an important regulator of myelination in the PNS, and its dysfunction results in arthrogryposis as observed in claw paw mice. ...

Preferred SH3 Domain Partners of ADAM Metalloproteases Include Shared and ADAM-Specific SH3 Interactions

A disintegrin and metalloproteinases (ADAMs) constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3) domain binding show a strong correlation. Here we present a comprehensive characterization of SH3 binding capacity and preferences of the catalytically active ADAMs 8, 9,...

LGI proteins in the nervous system

The development and function of the vertebrate nervous system depend on specific interactions between different cell types. Two examples of such interactions are synaptic transmission and myelination. LGI1-4 (leucine-rich glioma inactivated proteins) play important roles in these processes. They are secreted proteins consisting of an LRR (leucine-rich repeat) domain and a so-called epilepsy-ass...

Choosing and Using lGi , Child Victimization Questionnaires

The Office of Juvenile Justice and Delinquency Prevention (OJJDP) is committed to improuing the justice system's response to crimes against children. OJJDP recognizes that children are a t increased risk for crime uictimization. Not only are children the uictims of many of the same crimes that uictimize adults, they are subject to other crimes, like child abuse and neglect, that are specific to...

ADAM 10 ( ADAM metallopeptidase domain 10 )